Synthetic peptide, corresponding to the N-terminus of Human Topo IIalpha.
Conjugation:
Unconjugated
Alternative Names:
Topoisomerase II alpha 170 kDa, Topo II alpha, Topoisomerase DNA II alpha 170kDa, TopII alpha, TP2A, TOP2A, TOP2, TOP 2A, EC 5.99.1.3, DNA topoisomerase II alpha isozyme, DNA topoisomerase II 170 kD, DNA topoisomerase 2 alpha, DNA Topoisomerase2
DNA topoisomerase I and II (Topo I and Topo II) are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Eukaryotic topoisomerases are capable of relaxing both positive and negative supercoils, whereas prokaryotic topoisomerases relax only negative supercoils. DNA topoisomerases play a role in DNA replication, recombination and transcription and have been identified as targets of numerous anticancer drugs. Topo I, a ubiquitously expressed, soluble enzyme, acts by introducing a transient break in one strand of DNA, while Topo II acts by making a transient double-strand break. Topo II is encoded by two different genes to generate two distinct isoforms that are designated Topo IIalpha and Topo IIbeta.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
