Synthetic peptide, corresponding to the C-terminual of Human POM121.
Conjugation:
Unconjugated
Alternative Names:
Nuclear envelope pore membrane protein POM 121, Nuclear envelope pore membrane protein POM 121A, Nucleoporin Nup121, Pore membrane protein of 121 kDa, POM121, KIAA0618, NUP121, POM121A, Putative nuclear envelope pore membrane protein POM 121B, POM121B, Nuclear envelope pore membrane protein POM 121C, Nuclear pore membrane protein 121-2, POM121-2, Pore membrane protein of 121 kDa C, POM121C
POM121 (POM121 membrane glycoprotein), also known as POM121A (nuclear envelope pore membrane protein POM 121A), NUP121 (nucleoporin Nup121) or pore membrane protein of 121 kDa, is a 1,249 amino acid single-pass membrane protein that exists as three alternatively spiced isoforms and belongs to the POM121 family. Encoded by a gene that maps to human chromosome 7q11.23, POM121 is highly conserved and localizes to nucleus membrane and endoplasmic reticulum membrane. An essential component of the nuclear pore complex (NPC), POM121 is mandatory for nuclear envelope formation and may play a role in biogenesis of the NPC. POM121 associates with the central spoke ring complex and is involved in anchoring components of the pore complex to the pore membrane by way of its F-X-F-G repeat-containing domain. POM121 overexpression induces the formation of cytoplasmic annulate lamellae (AL).
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000 IHC: 1:50~1:200
Application Notes:
POM121 (K1249) polyclonal antibody detects endogenous levels of POM121 protein.
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