Synthetic peptide, corresponding to amino acids 371-420 of Human X11gamma.
Conjugation:
Unconjugated
Alternative Names:
Amyloid beta A4 precursor protein-binding family A member 3, Adapter protein X11gamma, Neuron-specific X11L2 protein, Neuronal Munc18-1-interacting protein 3, Mint-3, APBA3, MINT3, X11L2
Amyloid beta precursor protein (beta APP) is a major constituent of the amyloid deposits in patients with Alzheimers disease. The amyloid beta precursor is known to interact with several proteins, including the G heterotrimetric protein, APP-BP1, and X11. The neuronal, transmembrane protein X11 is known to bind to the amyloid beta precurser protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular beta APP and slowing beta APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of beta APP. Multiple splice varitents of X11 have been identified, including X11 alpha, beta and gamma (also known as Mint 1, 2 and 3, respectively).
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
IHC: 1:50~1:200
Application Notes:
X11gamma (R401) polyclonal antibody detects endogenous levels of X11gamma protein.
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