Synthetic peptide, corresponding to amino acids 100-146 of Human MDFI.
Conjugation:
Unconjugated
Alternative Names:
MyoD family inhibitor, Myogenic repressor I-mf, MDFI
MDFI is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. MDFI an also interfere with the DNA-binding activity of Myod family members and plays an important role in trophoblast and chondrogenic differentiation.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000 IF 1:50~1:200
Application Notes:
MDFI (P134) polyclonal antibody detects endogenous levels of MDFI protein.
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