Transcription factor that binds DNA in a sequence-specific manner.Participates in the Wnt signaling pathway (By similarity).Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity).PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity).TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1.Regulates T-cell receptor alpha enhancer function.Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity).May play a role in hair cell differentiation and follicle morphogenesis (By similarity).
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Application Dilute:
WB: 1:1000~1:2000 IF: 1:100~1:500
Application Notes:
LEF-1 polyclonal antibody detects endogenous levels of LEF-1 protein.
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