Inositol polyphosphate-5-phosphatase of 145 kDa, inositol polyphosphate-5-phosphatase, 145kDa, INPP5D, p150Ship,
SHIP an SH2-containing inositol phosphatase. A hemopoietic-specific phosphatase that regulates cell survival, growth, cell cycle arrest and apoptosis. Hydrolyzes Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3. A cytosolic protein with a SH2 domain in its N-terminus