PRP19 Rabbit monoclonal antibody, Unconjugated

Product Overview

• Article Name: PRP19 Rabbit monoclonal antibody, Unconjugated
• Biozol Catalog Number: BWT-BS40218
• Supplier Catalog Number: BS40218
• Alternative Catalog Number: BWT-BS40218-50UL,BWT-BS40218-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: FC, ICC, IHC, WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: A synthesized peptide derived from human PRP19
• Conjugation: Unconjugated
• Alternative Names: NMP200, nuclear matrix protein 200, pre-mRNA-processing factor 19, PRP19, PRP19/PSO4, PRPF19, PSO4, senescence evasion factor, SNEV, UBOX4,

Product Description

Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates Lys-63-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234).

Product Properties

• Molecular Weight: 55kDa
• UniProt: Q9UMS4
• Purity: Affinity-chromatography
• Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Application Notes

• Application Dilute: WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:50
• Application Notes: PRP19 Antibody detects endogenous levels of PRP19