E3 ubiquitin-protein ligase ZNRF2, ZNRF2, Zinc/RING finger protein 2, RNF202, Protein Ells2,
May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.