Death up-regulated gene protein, Dug, H731, Ma3, Neoplastic transformation inhibitor, Nuclear antigen H731, Pdcd4, Programmed cell death protein 4, Tis,
PDCD4 (programmed cell death protein 4) was identified as a suppressor of neoplastic transformation. It interacts with eukaryotic initiation factors eIF4AI and eIF4AII. PDCD4 colocalizes with eIF4A in the cytoplasm and inhibits the activity of eIF4A as a