IkB-epsilon (I-kappa-B-epsilon), also known as NFKBIE (NFkappaB inhibitor epsilon) or IKBE, is a 500 amino acid protein that belongs to the NFkappaB inhibitor family. Localizing to the cytoplasm, IkB-epsilon is highly expressed in spleen, testis and lung, with lower levels of expression found in kidney, pancreas, heart, placenta, brain, granulocytes and macrophages. IkB-epsilon inhibits c-Rel and NFkappaB subunits p50, p52 and p65 by forming a complex with them in the cytoplasm, preventing them from activating genes in the nucleus. IkB-epsilon undergoes serine phosphorylation, resulting in the protein being marked for destruction via the ubiquitination pathway.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
IHC:1:50~1:200
Application Notes:
p-IkB-epsilon (S22) polyclonal antibody detects endogenous levels of IkB-epsilon protein only when phosphorylated at Ser22
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