Synthetic phosphopeptide derived from human Troponin I3 around the phosphorylation site of Ser22/23.
Conjugation:
Unconjugated
Alternative Names:
Troponin I, cardiac muscle, Cardiac troponin I, TNNI3, TNNC1
Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. TnI inhibits ATPase activity of acto myosin and TnT and TnI are present in cardiac muscles in different forms than in skeletal muscles. Only one tissue specific isoform of TnI is described for cardiac muscle tissue (cTnI) and this is expressed only in myocardium.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000
Application Notes:
Troponin I3 (phospho-S22/S23) polyclonal antibod detects endogenous levels of Troponin I3 protein only when phosphorylated at Ser22 and Ser23.
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