Synthetic peptide, corresponding to amino acids 100-150 of Human Synuclein-alpha.
Conjugation:
Unconjugated
Alternative Names:
Alpha-synuclein, alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, SNCA, NACP, PARK1
The synuclein family members, including alpha-synuclein (also designated NACP for non-beta Amyloid component) and beta-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. alpha-synuclein is localized to neuronal cell bodies and synapses. alpha-synuclein was first identified as a component of Alzheimers disease amyloid plaques. Abnormal platelet function in Alzheimers disease has been demonstrated. During megakaryocytic differentiation alpha-synuclein has been found to be upregulated, while beta-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of alpha-synuclein has been found in patients with early onset Parkinsons disease.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
IHC: 1:50~1:200
Application Notes:
p-Synuclein-alpha (S129) polyclonal antibody detects endogenous levels of Synuclein-alpha protein only when phosphorylated at Ser129
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