Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in several processes, including leukocyte migration, positive regulation of cell migration, and regulation of cytokine production. Acts upstream of or within several processes, including cellular defense response, monocyte chemotaxis, and neutrophil clearance. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system, brain, genitourinary system, hemolymphoid system gland, and liver and biliary system. Used to study Coronavirus infectious disease and age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease, aggressive periodontitis, coronary artery disease (multiple), glucose metabolism disease (multiple), and uveitis (multiple). Orthologous to human CCR2 (C-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Store at -20C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
