Ubiquitin Protein Ligase E3A Recombinant Rabbit mAb, Unconjugated
Biozol Catalog Number:
BWT-BS45152
Supplier Catalog Number:
BS45152
Alternative Catalog Number:
BWT-BS45152-50UL,BWT-BS45152-100UL
Manufacturer:
Bioworld Technology
Host:
Rabbit
Category:
Antikörper
Application:
FC, ICC, IP, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Recombinant protein of human UBE3A
Conjugation:
Unconjugated
Alternative Names:
AS, ANCR, E6-AP, HPVE6A, EPVE6AP
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Store at -20C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
