Activin Receptor Type IA Recombinant Rabbit mAb, Unconjugated
Biozol Catalog Number:
BWT-BS46310
Supplier Catalog Number:
BS46310
Alternative Catalog Number:
BWT-BS46310-50UL,BWT-BS46310-100UL
Manufacturer:
Bioworld Technology
Host:
Rabbit
Category:
Antikörper
Application:
IP, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
A synthetic peptide of human Activin Receptor Type IA
Conjugation:
Unconjugated
Alternative Names:
FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
Store at -20C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Application Dilute:
WB: 1:1000-1:5000<br />IP: 1:20
Application Notes:
IgG
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