Synthetic phosphopeptide derived from human Dok-1 around the phosphorylation site of Tyrosine 362.
Conjugation:
Unconjugated
Alternative Names:
Docking protein 1 62kD, Docking protein 1, DOK 1, DOK1, DOK1, Downstream of tyrosine kinase 1, p62(dok), P62DOK, pp62
Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9,22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of ''docking proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
IHC: 1:50~1:200 IF: 1:50~1:200
Application Notes:
p-Dok-1 (Y362) polyclonal antibody detects endogenous levels of Dok-1 protein only when phosphorylated at Tyr362.
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