Gab 1 (phospho-Y627) polyclonal antibody, Unconjugated, Rabbit
Biozol Catalog Number:
BWT-BS4790
Supplier Catalog Number:
BS4790
Alternative Catalog Number:
BWT-BS4790-50UL,BWT-BS4790-100UL
Manufacturer:
Bioworld Technology
Host:
Rabbit
Category:
Antikörper
Application:
WB
Species Reactivity:
Human
Immunogen:
Synthetic phosphopeptide derived from human Gab 1 around the phosphorylation site of Tyrosine 627.
Conjugation:
Unconjugated
Alternative Names:
GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1
Gab 1 (GRB2-associated binder 1), one such member of the IRS family, plays an important role in cellular growth response, transformation and apoptosis. Gab 1 is a multi-substrate docking protein that functions downstream in the signaling pathways of different receptor kinases, including EGFR. Gab1 is tyrosine phosphorylated normally in response to insulin and consequently enhances phosphatidylinositol 3- kinase (PI3K) binding. In response to osmotic shock, tyrosine-phosphorylated Gab 1 (p-Gab 1) also binds and activates phosphatidylinositol 3-kinase, suggesting that Gab 1 is the major site for PI3K recruitment following osmotic shock stimulation.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000
Application Notes:
p-Gab 1 (Y627) polyclonal antibody detects endogenous levels of Gab 1 protein only when phosphorylated at Tyr627.
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