Synthetic phosphopeptide derived from human Tensin-1 around the phosphorylation site of Tyrosine 483.
Conjugation:
Unconjugated
Alternative Names:
Tensin-1, TNS1, TNS
Tensin is involved in the maintenance of cellular structure by anchoring Actin filaments at the focal adhesion via F-Actin binding and capping activities. However, tensin also contains a Src homology 2 (SH2) domain and has the ability to be phosphorylated. Tensin is phosphorylated on tyrosine, serine, and threonine residues, suggesting that it might participate in signal transduction cascades. These diverse characteristics in a single molecule indicate that tensin may be an important link between the cytoskeleton and signal transduction pathways.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
IHC: 1:50~1:200
Application Notes:
p-Tensin-1 (Y483) polyclonal antibody detects endogenous levels of Tensin-2 protein when phosphorylated at Tyr483.
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