p130 Cas (phospho-Y249) polyclonal antibody, Unconjugated, Rabbit
Biozol Catalog Number:
BWT-BS4849
Supplier Catalog Number:
BS4849
Alternative Catalog Number:
BWT-BS4849-50UL,BWT-BS4849-100UL
Manufacturer:
Bioworld Technology
Host:
Rabbit
Category:
Antikörper
Application:
ICC, IHC, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic phosphopeptide derived from human p130 Cas around the phosphorylation site of Tyrosine 249.
Conjugation:
Unconjugated
Alternative Names:
Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas scaffolding protein family member 1, p130cas, BCAR1, CAS, CASS1, CRKAS
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins. p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement and bacterial infection. Physiological functions of p130Cas include cardiovascular development, actin filament assembly and Src-induced cell transformation.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000 IHC: 1:50~1:200 ICC: 1:50~1:200
Application Notes:
p-p130 Cas (Y410) polyclonal antibody detects endogenous levels of p130 Cas protein only when phosphorylated at Tyr410.
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