CYP4F2 polyclonal antibody, Unconjugated, Rabbit

Product Overview

• Article Name: CYP4F2 polyclonal antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BWT-BS5690
• Supplier Catalog Number: BS5690
• Alternative Catalog Number: BWT-BS5690-50UL,BWT-BS5690-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: ICC, IHC, IP, WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide, corresponding to amino acids 76-121 of Human CYP4F2.
• Conjugation: Unconjugated
• Alternative Names: Leukotriene-B(4) omega-hydroxylase 1, CYPIVF2, Cytochrome P450 4F2, Cytochrome P450-LTB-omega, Leukotriene-B(4) 20-monooxygenase 1

Product Description

CYP4F isoforms are involved in the oxidation of important cellular mediators, such as leukotriene B4 (LTB4) and prostaglandins. CYP4F2 catalyzes omega-hydroxylation of LTB4 to a less potent proinflammatory eicosanoid, 20-OH-LTB4 as well as arachidonic acid. CYP4F2 is expressed in liver and kidney. Its expression is repressed by peroxisomal proliferators and induced by retinoic acid. X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder biochemically characterized by elevated levels of very long-chain fatty acids (VLCFA). CYP4F2 participates in the omega-hydroxylation of VLCFAs, which may provide an alternative mode of treatment for X-ALD patients.

Product Properties

• Molecular Weight: ~ 60 kDa
• UniProt: P78329
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Application Notes

• Application Dilute: WB: 1:500~1:1000 IHC: 1:50~1:200 ICC: 1:50~1:200 IP: 1:50~1:200
• Application Notes: CYP4F2 polyclonal antibody detects endogenous levels of CYP4F2 protein.