A synthetic peptide corresponding to residues in Human ZBTB7A
Conjugation:
Unconjugated
Alternative Names:
Zinc finger and BTB domain-containing protein 7A, Factor binding IST protein 1, FBI-1, Factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor, POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21, TIP21, Zinc finger protein 857A, ZBTB7A, FBI1, LRF, ZBTB7, ZNF857A
LRF, formerly identified as Pokemon, is a poxvirus zinc finger (POZ) domain-containing transcription factor that influences cell differentiation. LRF (for leukemia/lymphoma related factor) is also known as zinc finger and BTB domain containing 7A, ZBTB7, TIP21, FBI1 and FBI-1. POZ-domain transcription factors contain a POZ or BTB type protein-protein interaction domain at their N-terminus and Kruppel-type zinc fingers at their C-terminus. LRF is inducible during both murine and human preadipocyte differentiation and may contrib-ute to adipogenesis through influencing the switch from cellular proliferation to terminal differentiation. LRF can associate with active chromatin and stimulate TAT-activated HIV-1 transcription through interactions with the HIV-1 long terminal repeat. 3T3L1 cells stably overexpressing LRF show a reduction in DNA synthesis and in expression of cyclin A, cyclin-dependent kinase 2 and p107.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000
Application Notes:
ZBTB7A polyclonal antibody detects endogenous levels of ZBTB7A protein.
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