A synthetic peptide corresponding to residues in Human TBC1D2.
Conjugation:
Unconjugated
Alternative Names:
TBC1 domain family member 2A, Armus, Prostate antigen recognized and identified by SEREX 1, PARIS-1, BC1D2, PARIS1, PP8997, TBC1D2A
GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. TBC1D2 (TBC1 domain family member 2), also known as Armus or PARIS-1 (prostate antigen recognized and identified by SEREX 1), is a 928 amino acid protein containing a Rab-GAP TBC domain and a PH domain. Localizing to cytoplasm, cytoplasmic vesicles and cell junctions, TBC1D2 is expressed in a broad range of tissues, including kidney, liver, lung and placenta, as well as in keratinocytes and epithelia-containing organs. TBC1D2 functions as a GTPase-activating protein for RAB7, and also acts as a linker between RAB7 and RAC1, which leads to RAB7A inactivation and inhibition of E-cadherin degradation. Existing as six alternatively spliced isoforms, the gene encoding TBC1D2 maps to human chromosome 9q22.33.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000
Application Notes:
TBC1D2 polyclonal antibody detects endogenous levels of TBC1D2 protein.
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