A synthetic peptide corresponding to residues in Human DFFB.
Conjugation:
Unconjugated
Alternative Names:
DNA fragmentation factor subunit beta (EC:3.-.-.-), Caspase-activated deoxyribonuclease, CAD, Caspase-activated DNase, CPAN, DNA fragmentation factor 40 kDa subunit, DFF-40, DFFB
The Ced/ICE or caspase family of cysteine proteases plays a pivotol role in mediating apoptosis through the proteolysis of specific targets. Among the targets are poly(ADP-ribose) polymerase (PARP), Gelsolin, ICAD (inhibitor of CAD, also designated DFF-45) and the nuclear lamins. CAD (caspase-activated deoxyribonuclease), also designated CPAN (caspase-activated nuclease) and DFF40, is a DNase that is responsible for DNA degradation during apoptosis. Caspase-3 acts to dissociate CAD from ICAD, allowing CAD to enter the nucleus and degrade DNA.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000
Application Notes:
DFFB polyclonal antibody detects endogenous levels of DFFB protein.
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