A synthetic peptide corresponding to residues in Human A2M.
Conjugation:
Unconjugated
Alternative Names:
Alpha-2-macroglobulin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5
alpha-2-Macroglobulin (alpha-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, alpha-2M was characterized as a pan-proteinase inhibitor thatwas able to ''bait proteinases into cleaving specific peptide sequences on alpha-2M. This interaction induces a conformational change in alpha-2M, thus enabling it to ''trapthe proteinase and inhibit its further activity. Subsequently, alpha-2M has also been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor beta (TGFbeta) in serumis primarily bound to alpha-2M,which renders TGFbeta inactive. alpha-2M also binds to IL-6 and, thereby, increasesthe concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved inmediating the inflammatory cascade. Mutations and deletions in the gene encoding alpha-2M are associated with an increased incidence of Alzheimers Disease (AD),which isconsistent with the role of alpha-2M inmediating the clearance and degradation of Abeta, the major component of beta-Amyloid deposits accumulated during AD.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000 IHC: 1:50~1:203
Application Notes:
A2M polyclonal antibody detects endogenous levels of A2M protein.
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