IRF-4 polyclonal antibody, Unconjugated, Rabbit

Product Overview

• Article Name: IRF-4 polyclonal antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BWT-BS6104
• Supplier Catalog Number: BS6104
• Alternative Catalog Number: BWT-BS6104-50UL,BWT-BS6104-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: IF, IHC, WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IRF4.
• Conjugation: Unconjugated
• Alternative Names: MUM1, Interferon regulatory factor 4, IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5

Product Description

Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5-TGAnTCA/GAAA-3), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes

Product Properties

• Molecular Weight: ~ 47 kDa
• UniProt: Q15306
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Application Notes

• Application Dilute: WB: 1:500~1:1000 IHC: 1:100~1:200 IF/ICC: 1:100~1:500
• Application Notes: IRF4 polyclonal antibody detects endogenous levels of IRF4 protein.