39S ribosomal protein L39, mitochondrial, L39mt, MRP-L39, 39S ribosomal protein L5, mitochondrial, L5mt, MRP-L5, Mitochondrial large ribosomal subunit protein mL39, MRPL39, C21orf92, MRPL5, RPML5, MSTP003, PRED22
Mitochondrial ribosomes consist of a large 39S subunit and a small 28S subunit, both of which are comprised of multiple mitochondrial ribosomal proteins (MRPs) that are encoded by nuclear genes and are essential for protein synthesis within mitochondria. MRP-L39 (mitochondrial ribosomal protein L39), also known as MRP-L5, L39mt or L5mt, is a 338 amino acid mitochondrial protein that exists as a component of the 39S ribosomal subunit and works in conjunction with other MRPs to mediate protein synthesis. MRP-L39 exists as two isoforms produced by alternative splicing. Isoform one of MRP-L39 is ubiquitously expressed while isoform two is specifically expressed in heart. The gene encoding MRP-L39 maps to chromosome 21, which makes up about 1.5% of the human genome. Chromosome 21 contains nearly 300 genes and 47 million base pairs. Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21. Alzheimers disease, Jervell and Lange-Nielsen syndrome and amyotrophic lateral sclerosis are also associated with chromosome 21.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000
Application Notes:
MRPL39 polyclonal antibody detects endogenous levels of MRPL39 protein.
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