Dynein regulatory complex subunit 4, Growth arrest-specific protein 11, GAS-11, Growth arrest-specific protein 8, GAS-8, GAS8, DRC4,GAS11
Gas8 (growth arrest-specific 8), also known as Gas11, is a 478 amino acid protein that localizes to the Golgi apparatus, as well as to the cytoplasm and the flagellar basal body, and belongs to the growth arrest-specific protein family. Expressed in liver, heart and skeletal muscle with lower levels present in lung, brain, kidney and placenta, Gas8 functions as a cytoskeletal linker that binds microtubules and is thought to play a role in axonemal and non-axonemal dynein regulation. Gas8 may also be involved in spermatozoa motility and, when defective, may be associated with infertility in males lacking gametocytes. The gene encoding Gas8 maps to a region on human chromosome 16 that is frequently deleted in breast and prostate cancer, suggesting a role for Gas8 in tumorigenesis.
