Homeobox protein Nkx-2.4, Homeobox protein NK-2 homolog D, NKX2-4, NKX2D
TTF-1 (thyroid transcription factor-1, BCH, BHC, NK-2, Nkx2.1, Nkx2A, TEBP, TTF1) is a member of the Nkx2 family of homeodomain-containing transcription factors and regulates the transcriptional activity of thyroid-specific genes. TTF-1 influences organogenisis and the maintenance of the differentiated phenotypes of various tissues including thyroid, lung and brain. TTF-1, which is present in the epithelium of the lung, regulates transcription of the surfactant proteins (SP) A, B and C and is essential for lung morphogenesis. In the thyroid, TTF-1 elevates the expression of thyroid specific markers, thyroglobulin, thyroperoxidase and thyrotropin receptors. TTF-1 interacts with SRC-1 and CBP in vitro.
