Cathepsin L HC polyclonal antibody, Unconjugated, Rabbit
Biozol Catalog Number:
BWT-BS62559
Supplier Catalog Number:
BS62559
Alternative Catalog Number:
BWT-BS62559-50UL,BWT-BS62559-100UL
Manufacturer:
Bioworld Technology
Host:
Rabbit
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide, corresponding to Human Cathepsin L HC.
Conjugation:
Unconjugated
Alternative Names:
Cathepsin L1, Cathepsin L, Major excreted protein, MEP, CTSL, CTSL1
The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Cathepsin G is in the serine protease class. Most cathepsins are lysosomal and each is involved in cellular metabolism, participating in various events such as peptide biosynthesis and protein degradation. Cathepsin L (also designated major excreted protein, MEP or CATL) is a member of the peptidase C1 family and has been identified as a protein that is most closely related to cathepsin H. It is a lysosomal cysteine proteinase that mediates intracellular protein catabolism for collagen, elastin and a-1 protease inhibitor. Cathepsin L is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene. Transformed mouse fibroblasts stimulated by growth factors or tumor promoters secrete a form of cathepsin L.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB:1:500~1:1000 IHC:1:50~1:200
Application Notes:
Cathepsin L HC polyclonal antibody detects endogenous levels of Cathepsin L HC protein.
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