MAX (phospho-S11) polyclonal antibody, Unconjugated, Rabbit
Biozol Catalog Number:
BWT-BS64009
Supplier Catalog Number:
BS64009
Alternative Catalog Number:
BWT-BS64009-50UL,BWT-BS64009-100UL
Manufacturer:
Bioworld Technology
Host:
Rabbit
Category:
Antikörper
Application:
WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic phosphopeptide derived from human MAX around the phosphorylation site of Serine 11.
Conjugation:
Unconjugated
Alternative Names:
Protein max, Class D basic helix-loop-helix protein 4, bHLHd4, Myc-associated factor X, BHLHD4
It is now well established that the nature and relative abundance of individual subunits of different classes of transcription factors can positively or negatively regulate levels of gene expression. Myc proteins homodimerize and bind DNA poorly, if at all, at physiological levels. Max is a nuclear localized bHLH-Zip protein initially identified by screening a B cell expression library with the bHLH-Zip region of c-Myc. Max homodimers and the Myc-Max heterodimers bind the sequence CACGTG, however the binding of the hetero-dimeric complex is stronger than the Max homodimer. The Max gene products have been identified as Max and Max 9 proteins that differ by a 9 amino acid insertion N-terminal to the basic region. In contrast to Myc, which is highly regulated during progression through the cell cycle, Max is highly stable and is much more abundant than Myc. Two members of the bHLH-Zip protein family, designated Mad and Mxi1, homodimerize poorly but form heterodimeric complexes with Max that have opposing functions to Myc-Max heterodimers with respect to regulation of gene expression.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000
Application Notes:
p-MAX(S11) polyclonal antibody detects endogenous levels of MAX protein only when phosphorylated at Ser11.
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