Synthetic phosphopeptide derived from human DAB1 around the phosphorylation site of Tyrosine 220.
Conjugation:
Unconjugated
Alternative Names:
Disabled homolog 1, DAB1
Dab1, a homolog of the Drosophila disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl. Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants. Reelin is a secreted protein thought to play a role in directing migrating neurons. Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain. Dab2 (also designated DOC-2) is a mitogen-responsive phosphoprotein that binds the SH3 domain of GRB2, and it is thought to be a negative regulator of growth.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Application Dilute:
WB: 1:500~1:1000
Application Notes:
DAB1(Phospho-Y220) polyclonal antibody detects endogenous levels of DAB1 protein only when phosphorylated at Tyr220.
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