Synthetic phosphopeptide derived from human BLK around the phosphorylation site of Tyrosine389.
Conjugation:
Unconjugated
Alternative Names:
Tyrosine-protein kinase Blk, B lymphocyte kinase, p55-Blk, BLK
Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development. Activation of B cells by various ligands is accompanied by activation of Blk. It has been suggested that Blk is involved in the control of B cell differentiation and proliferation. Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis. Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000
Application Notes:
BLK (phospho-Y389) polyclonal antibody detects endogenous levels of BLK protein only when phosphorylated at Tyr389 .
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