Lamin A/C (Phospho-S392) polyclonal antibody, Unconjugated, Rabbit

Product Overview

• Article Name: Lamin A/C (Phospho-S392) polyclonal antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BWT-BS65001
• Supplier Catalog Number: BS65001
• Alternative Catalog Number: BWT-BS65001-50UL,BWT-BS65001-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: IF, IHC, WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic phosphopeptide derived from human Lamin A/C around the phosphorylation site of Serine 392.
• Conjugation: Unconjugated
• Alternative Names: Prelamin-A/C, Lamin-A/C, Lamin A/C, LaminA/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMNA, LMN1, Lamin A, LaminA, Lamin-A, Lamin C, LaminC, Lamin-C

Product Description

Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

Product Properties

• Molecular Weight: ~ 74, 65 kDa
• UniProt: P02545
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Application Notes

• Application Dilute: WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200
• Application Notes: Lamin A/C (Phospho-S392) polyclonal antibody detects endogenous levels of Lamin A/C protein only when phosphorylated at Ser392.