Bovine, Canine, Gallus, Human, Mouse, Porcine, Rabbit, Rat, Sheep
Immunogen:
KLH conjugated synthetic peptide derived from human Sema3F:201-300/785
Conjugation:
Unconjugated
Alternative Names:
Semaphorin-3F, Semaphorin3F, Sema III/F, Sema IV, sema3F, SemaIII/F, SemaIV, Semaphorin IV, SemaphorinIV, SEM3F_HUMAN.
The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues(Kolodkin et al., 1993 [PubMed 8269517]). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A, MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993 [PubMed 8402908]) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995 [PubMed7637782]), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.
