Bovine, Canine, Equine, Gallus, Human, Mouse, Porcine, Rabbit, Rat
Immunogen:
KLH conjugated synthetic peptide derived from human PITX3:231-302/302
Conjugation:
Unconjugated
Alternative Names:
Homeobox protein PITX 3, Homeobox protein PITX3, MGC12766, Paired like homeodomain transcription factor 3, Paired-like homeodomain transcription factor 3, Pituitary homeobox 3, PITX 3, Pitx3, PITX3_HUMAN, PTX 3, PTX3.
The transcription factor PITX3 is expressed selectively in the midbrain and regulates the differentiation and survival of dopaminergic neurons. Lack of this factor results in a degeneration similar to that seen in Parkinsons disease. PITX3 is also important in eye developement, mutations of the PITX3 gene have been associated with a familial form of cataracts.
