KLH conjugated synthetic peptide derived from human PTPRJ:865-970/1337
Conjugation:
Unconjugated
Alternative Names:
CD 148, CD148, CD148 antigen, Density enhanced phosphatase 1, Density-enhanced phosphatase 1, DEP 1, DEP-1, HPTP eta, HPTPeta, Human density enhanced phosphatase 1, Protein tyrosine phosphatase eta, Protein tyrosine phosphatase receptor type J, Protein tyrosine phosphatase receptor type J polypeptide, Protein-tyrosine phosphatase eta, Protein-tyrosine phosphatase receptor type J, PTPJ, Ptprj, PTPRJ_HUMAN, R PTP Eta, R-PTP-eta, R-PTP-J, Receptor type tyrosine protein phosphatase eta, Receptor-type tyrosine-protein phosphatase eta, SCC 1, SCC1.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
