Phospho-PERK (Thr980) Polyclonal Antibody, Unconjugated, Rabbit

Product Overview

• Article Name: Phospho-PERK (Thr980) Polyclonal Antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BWT-BS65625
• Supplier Catalog Number: BS65625
• Alternative Catalog Number: BWT-BS65625-50UL,BWT-BS65625-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: IHC, WB
• Species Reactivity: Human, Mouse
• Immunogen: KLH-conjugated synthetic phosphopeptide corresponding to residues surrounding T980 of human PERK protein.
• Conjugation: Unconjugated
• Alternative Names: p-PERK(Thr980), PERK(Phospho Thr980), PERK(Phospho T980), HRI, HsPEK, Pancreatic eIF2-alpha kinase, PEK, PRKR like endoplasmic reticulum kinase, WRS, DKFZp781H1925, EC 2.7.11.1, EIF2AK3, Eukaryotic translation initiation factor 2 alpha kinase 3, Heme regulated EIF2 alpha kinase.

Product Description

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010].

Product Properties

• Molecular Weight: ~ 140 kDa
• UniProt: Q9NZJ5
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Application Notes

• Application Dilute: WB: 1:500~1:1000 IHC: 1:100~1:200
• Application Notes: Phospho-PERK (Thr980) Polyclonal Antibody detects endogenous levels of Phospho-PERK protein only when phosphorylated at Thr980