Bovine, Canine, Equine, Human, Mouse, Porcine, Rabbit, Rat, Sheep
Immunogen:
KLH conjugated synthetic peptide derived from human MDMX:301-400/490
Conjugation:
Unconjugated
Alternative Names:
Double minute 4, Double minute 4 human homolog of p53 binding protein, Double minute 4 protein, HDMX, MDM 4, Mdm2 like p53 binding protein, Mdm2-like p53-binding protein, MDM4, Mdm4 p53 binding protein homolog mouse, Mdm4 protein, MDM4 related protein 1, Mdm4 transformed 3T3 cell double minute 4, Mdm4 transformed 3T3 cell double minute 4 p53 binding protein, Mdm4 transformed 3T3 cell double minute 4 p53 binding protein mouse, MDM4_HUMAN, Mdmx protein, Mouse double minute 4 homolog, Mouse double minute 4 human homolog of, Mouse double minute 4 human homolog of p53 binding protein, MRP 1, MRP1, p53 binding protein, p53 BINDING PROTEIN MDM4, p53-BINDING PROTEIN MDM4, Protein Mdm4, Protein Mdmx.
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2.
