Platelet glycoprotein 4, PAS-4, Platelet glycoprotein IV, Glycoprotein IIIb, GPIV, GPIIIB, GP3B, Leukocyte differentiation antigen CD36, PAS IV, Platelet collagen receptor, Fatty acid translocase, FAT, Thrombospondin receptor, CD_antigen: GP4, CD36_HUMAN.
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene.
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
