MHC class I Recombinant Rabbit mAb, Unconjugated

Product Overview

• Article Name: MHC class I Recombinant Rabbit mAb, Unconjugated
• Biozol Catalog Number: BWT-BS66218
• Supplier Catalog Number: BS66218
• Alternative Catalog Number: BWT-BS66218-50UL, BWT-BS66218-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human MHC class I.
• Conjugation: Unconjugated
• Alternative Names: HLAA, HLA class I histocompatibility antigen, A-1 alpha chain, MHC class I antigen A*1, HLAB, HLA class I histocompatibility antigen, B-7 alpha chain, MHC class I antigen B*7, HLAA, HLA class I histocompatibility antigen, A-68 alpha chain, Aw-68, HLA class I histocompatibility antigen, A-28 alpha chain, MHC class I antigen A*68, HLAA, HLA class I histocompatibility antigen, A-2 alpha chain, MHC class I antigen A*2, HLAA, HLA class I histocompatibility antigen, A-11 alpha chain, MHC class I antigen A*11, HLAA, HLA class I histocompatibility antigen, A-30 alpha chain, MHC class I antigen A*30, HLAA, HLA class I histocompatibility antigen, A-26 alpha chain, MHC class I antigen A*26

Product Description

The human leukocyte antigen (HLA) system is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. These cell surface proteins are responsible for the regulation of antigen-specific immunity in humans. HLA genes are highly polymorphic, allowing them to fine-tune the adaptive immune response. HLAs corresponding to MHC class I (HLA-A, B, and C) present small peptide antigens from inside the cell, approximately 8 to 10 amino acids in length, to CD8+ T lymphocytes in order to activate a cytotoxic T cell response. HLAs corresponding to MHC class II (HLA-DP, DM, DO, DQ, and DR) present antigens from outside of the cell, approximately 15 to 24 residues in length, to CD4+ T helper cells, which in turn secrete cytokines and stimulate B cells to produce antibodies to that specific antigen. HLAs corresponding to MHC class III encode components of the complement system.

Product Properties

• Molecular Weight: ~ 41 kDa
• UniProt: P30443
• Purity: The antibody was affinity-purified from cell culture supernatant by protein A+G and the purity is > 95% (by SDS-PAGE).
• Form: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Application Notes

• Application Dilute: WB,1:500 - 1:1000
• Application Notes: MHC class I mAb detects endogenous levels of MHC class I protein.