Synthetic peptide, corresponding to amino acids 141-190 of Human Caspase-6.
Conjugation:
Unconjugated
Alternative Names:
MCH2, CASP6, Caspase-6, Caspase 6, Caspase6
Caspase-6 (Mch2) is one of the major executioner caspases functioning in cellular apoptotic processes. Upon apoptotic stimulation, initiator caspases such as caspase-9 are cleaved and activated. The activated upstream caspases further process downstream executioner caspases, such as caspase-3 and caspase-6, by cleaving them into large and small subunits, thereby initiating a caspase cascade leading to apoptosis. One of the major targets for caspase-6 is the membrane associated protein lamin A. The cleavage of this protein causes cell membrane malfunction, membrane blebbing and eventual cell death.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
IHC: 1:50~1:200
Application Notes:
Caspase-6 p18 (D162) polyclonal antibody detects endogenous levels of the large subunit of active caspase-6 resulting from cleavage at Asp162 in mouse and rat (18 kDa). This antibody does not recognize other cleaved caspases.
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