Recombinant fusion protein of human ALKBH5(NP_060228.3).
Conjugation:
Unconjugated
Alternative Names:
ALKBH5,ABH5,OFOXD,OFOXD1
Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6-methyladenosine (m6A RNA, the most prevalent internal modification of messenger RNA (mRNA in higher eukaryotes. Can also demethylate N(6-methyladenosine in single-stranded DNA (in vitro. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export. Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3-UTR mRNAs in male germ cells (By similarity.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB,1:500 - 1:2000|IHC,1:50 - 1:200
Application Notes:
Polyclonal Antibodies
* VAT and and shipping costs not included. Errors and price changes excepted
