MTMR6 polyclonal antibody, Unconjugated, Rabbit

Product Overview

• Article Name: MTMR6 polyclonal antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BWT-BS72570
• Supplier Catalog Number: BS72570
• Alternative Catalog Number: BWT-BS72570-50UL,BWT-BS72570-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant fusion protein of human MTMR6(NP_004676.3).
• Conjugation: Unconjugated
• Alternative Names: MTMR6

Product Description

Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3P and phosphatidylinositol 3,5-bisphosphate (Probable. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5P2 but also to phosphatidylinositol 3-phosphate (PtdIns(3P, phosphatidylinositol 4-phosphate (PtdIns(4P, and phosphatidylinositol 5-phosphate (PtdIns(5P, phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport (By similarity. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+ T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels.

Product Properties

• Molecular Weight: 72kDa
• UniProt: Q9Y217
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Application Notes

• Application Dilute: WB,1:200 - 1:2000
• Application Notes: Polyclonal Antibodies