Recombinant fusion protein of human ZNF281(NP_036614.1).
Conjugation:
Unconjugated
Alternative Names:
ZNF281,ZBP-99,ZNP-99
Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB,1:1000 - 1:3000|IHC,1:50 - 1:200
Application Notes:
Unmodification
* VAT and and shipping costs not included. Errors and price changes excepted
