2A-DUB, 2ADUB, Histone H2A deubiquitinase, Histone H2A deubiquitinase MYSM1, KIAA1915, Myb like SWIRM and MPN domains 1, Myb like, SWIRM and MPN domain containing protein, Myb like, SWIRM and MPN domains 1, Myb-like, Myb-like, SWIRM and MPN domains 1, MYSM 1, mysm1, MYSM1 Myb-like, SWIRM and MPN domains 1, MYSM1_HUMAN, RP4-592A1.1, SWIRM and MPN domain-containing protein 1,
MYSM1 (myb-like, SWIRM and MPN domains 1), also known as 2ADUB or KIAA1915, is an 828 amino acid nuclear protein that contains one SWIRM domain, one SANT domain and one MPN domain and exists as multiple alternatively spliced isoforms. Expressed ubiquitously with highest expression in kidney, brain and spleen, MYSM1 functions to bind double-stranded DNA and may positively regulate the transcriptional activity of AR (androgen receptor), possibly via control of histone acetylation and deubiquitination. The gene encoding MYSM1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinsons Disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB 1:500 - 1:2000
Application Notes:
MYSM1 polyclonal antibody detects endogenous levels of MYSM1 protein.
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