Recombinant fusion protein of human CRACR2A(NP_001138430.1).
Conjugation:
Unconjugated
Alternative Names:
CRACR2A,EFCAB4B
[Isoform 1]: Ca(2+-binding protein that plays a key role in store-operated Ca(2+ entry (SOCE in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+ concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+ resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB,1:500 - 1:2000|IHC,1:50 - 1:200
Application Notes:
Unmodification
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