A6 related protein, A6-related protein, A6r, A6RP, hA6RP, MSTP011, Protein tyrosine kinase 9 like, Protein tyrosine kinase 9-like, PTK 9L, PTK9L, PTK9L protein tyrosine kinase 9 like, TWF 2, Twf2, TWF2_HUMAN, Twinfilin 1 like protein, Twinfilin 2, Twinfilin actin binding protein homolog 2, Twinfilin like protein, Twinfilin-1-like protein, Twinfilin-2, Twinfilin2,
Twinfilin-2, also known as TWF2, A6r, A6RP or PTK9L, is a 349 amino acid protein that localizes to the perinuclear region of the cytoplasm, as well as to the cytoskeleton, and contains two ADF-H domains. Expressed ubiquitously, Twinfilin-2 functions as an Actin-binding protein that is able to both bind and sequester G-Actin and cap the barbed ends of Actin filaments, thereby inhibiting Actin polymerization and playing a role in Actin-related motile and morphological processes. Twinfilin-2 is subject to post-translational phosphorylation by PKC zeta. The gene encoding Twinfilin-2 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:20 - 1:50
Application Notes:
TWF2 polyclonal antibody detects endogenous levels of TWF2 protein.
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