KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SOCS3.
Conjugation:
Unconjugated
Alternative Names:
SOCS3,ATOD4,CIS3,Cish3,SOCS-3,SSI-3,SSI3
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB,1:500 - 1:1000|IF/ICC,1:50 - 1:200
Application Notes:
SOCS3 polyclonal antibody detects endogenous levels of SOCS3 protein.
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