KCD2, KCND 2, KCND2, KCND2_HUMAN, KIAA1044, MGC119702, MGC119703, Potassium voltage gated channel Shal related subfamily member 2, Potassium voltage-gated channel subfamily D member 2, RK 5, RK5, Voltage gated potassium channel Kv4.2, Voltage gated potassium channel subunit Kv4.2, Voltage sensitive potassium channel, Voltage-gated potassium channel subunit Kv4.2,
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming a-subunits (KValpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KVbeta subunits that modify the gating properties of the coexpressed KValpha subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:2000 IHC: 1:50~1:200
Application Notes:
KV4.2 polyclonal antibody detects endogenous levels of KV4.2 protein.
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