Histone H4 (Acetyl-K12) polyclonal antibody, Unconjugated, Rabbit
Catalog Number:
BWT-BS8010
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| Article Name: | Histone H4 (Acetyl-K12) polyclonal antibody, Unconjugated, Rabbit |
| Biozol Catalog Number: | BWT-BS8010 |
| Supplier Catalog Number: | BS8010 |
| Alternative Catalog Number: | BWT-BS8010-50UL,BWT-BS8010-100UL |
| Manufacturer: | Bioworld Technology |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | IHC, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide including acetyl-lysine 12 of Histone H4. |
| Conjugation: | Unconjugated |
| Alternative Names: | Histone H4, HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4 |
| In eukaryotes, DNA is wrapped around histone octamers to form the basic unit of chromatin structure. The octamer is composed of histones H2A, H2B, H3 and H4, and it associates with approximately 200 base pairs of DNA to form the nucleosome. The association of DNA with histones results in dense packing of chromatin, which restricts proteins involved in gene transcription from binding to DNA. p300 preferentially acetylates Histone H3 at lysines 14 and 18 and Histone H4 at lysines 5 and 8. PCAF in its native form, primarily acetylates Histone H3 at lysine 14 to a monoacetylated form, and less efficiently acetylates Histone H4 at lysine 8. Histone H4 may also be acetylated at lysines 12 and 16, and the involvement of acetylated H4 with Histones H2A, H2B and H3 suggests that acetylated histones may be involved in dynamic chromatin remodeling. |
| Molecular Weight: | ~ 11 kDa |
| UniProt: | P62805 |
| Purity: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Form: | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
| Application Dilute: | WB: 1:500~1:1000 IHC: 1:50~1:200 |
| Application Notes: | Ac-Histone H4 (K12) polyclonal antibody detects endogenous levels of Histone H4 protein only when acetylated at K12. |
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